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Get Complete Medical Information About Clozapine Including Its Uses, Side Effects, Interactions, Expert Advice, Faqs Of Clozapine On



CLOZAPINE belongs to a group of medicines called antipsychotics. CLOZAPINE is used to treat people with schizophrenia in whom other medicines have not worked. CLOZAPINE is also used to treat severe disturbances in the emotions, thoughts and behavior of people with Parkinson’s disease in whom other medicines have not worked.

Common side-effects

• Severe constipation
• Fast heart beat
• Seizures
• Sudden fainting
• Light-headedness
• Dizziness

It is not necessary for all people to experience the above side-effects.


• Take CLOZAPINE only when prescribed by a doctor irrespective of meals, but at the same time daily.
• CLOZAPINE is usually not recommend for children and adolescents under 16 years of age. Always consult a doctor before giving it to your child.
• Inform your doctor if you are suffering from a condition called dementia before taking CLOZAPINE.
• Avoid taking CLOZAPINE if you have a low white blood cell count, if you have been treated with long-acting depot injections of antipsychotics, if you suffer from bone marrow disease or have a history of bone marrow disease, uncontrolled epilepsy, acute mental illness caused by alcohol or drugs, if you suffer from reduced consciousness and severe drowsiness, if you suffer from circulatory collapse which may occur as a result of severe shock, if you suffer from any severe kidney disease, if you suffer from myocarditis, if you suffer from any other severe heart disease, active liver disease such as jaundice. If anyone of the above applies and is true do not take CLOZAPINE. Talk to your doctor for more details.
• Seek medical help immediately if you get signs of a cold, fever, flu-like symptoms, sore throat or any other infection, rapid increase in body temperature, rigid muscles; if you have fast and irregular heartbeat, even when you are at rest, palpitations, breathing problems, chest pain or unexplained tiredness, constipation, abdominal pain, bloating.
• Drive only if you are mentally alert and physically stable after consuming CLOZAPINE.
• Always keep your doctor informed about the ongoing medication or the ones which you have taken in the past, including over-the-counter medicines and herbal medicines.


Q. How does CLOZAPINE work?
A. CLOZAPINE belongs to a group of medicines called anti-psychotic. CLOZAPINE works by blocking receptors in the brain for several neurotransmitters including dopamine type 4 receptors, serotonin type 2 receptors, acetylcholine receptors, norepinephrine receptors and histamine receptors.

Q. Does CLOZAPINE cause agranulocytosis?
A. Yes, CLOZAPINE is known to cause agranulocytosis (lowered white blood cell count) when taken along with medicines like carbamazepine, co-trimoxazole, phenylbutazone, penicillamine, cytotoxic agents, some medicines used in chemotherapy, long-acting depot injections of antipsychotic medicines. Please keep your doctor informed about your ongoing medications before taking CLOZAPINE.

Q. Can I take CLOZAPINE with birth-control tablets?
A. No, you are advised not to take CLOZAPINE at the same time with birth-control tablets. Since taking both at the same time may affect the medicine efficacy of CLOZAPINE.

Q. Can I take CLOZAPINE with HIV medications?
A. No, you are advised not to take CLOZAPINE at the same time with HIV medications such as protease inhibitors. Since taking them together can lead to unwanted side effects and poor efficacy of CLOZAPINE further leading to degradation of health.

Q. Can I take CLOZAPINE with antidepression medications?
A No, you are advised not to take CLOZAPINE along with antidepression medications like lithium, fluvoxamine, tricyclic antidepressants, MAO inhibitors, paroxetine, citalopram, fluoxetine, and sertraline inhibitors. Since taking both of them together may lead to poor medicine efficacy leading to unwanted depression. Speak with your doctor, your doctor may prescribe you an alternative medication.

Q. Can CLOZAPINE induce sleep?
A. Yes, CLOZAPINE makes you feel tired, drowsy especially at the beginning of treatment. Your doctor may gradually increase your dose to minimize the risk of the above side-effects. You are advised not drive or operate machines while you have these symptoms.

Q. Can I stop CLOZAPINE on my own?
A. No, you are advised not to stop taking CLOZAPINE on your own, because you may experience withdrawal symptoms such as sweating, headache, vomiting and diarrhoea. If you experience any of the above symptoms, tell your doctor immediately. Also, these symptoms may be followed by more serious side effects unless you are treated immediately.